Aaron Helzinger, also known as Amygdala, became a colossus filled with rage and insensitivity after a botched operation. He is used by many villains to pose a real threat to Batman.

Come hear the sad story of Mr. Freeze. The famous scientist specializing in cryogenics, Victor Fries, worked for Wayne Industries. He discovered that his wife was terminally ill and did everything he could to save her. Ultimately, he decided to freeze her while he searched for a cure. To this misfortune, an accident occurred, exposing him to his cryogenic liquids. Now, he can only live at very low temperatures.
That is why he created an insulating suit equipped with a terrible weapon that freezes his victims and shoots ice.

Deacon Blackfire is a preacher with extreme charisma. This evangelist gathers the poor of Gotham City around him. They serve and protect the deacon. He can manipulate minds, breaking them to bring them under his control. His power should not be underestimated, as even Batman nearly became his puppet. How long has he been exercising this power? No one knows, as he claims to be immortal.

Lonnie Machin is the supervillain Anarky. He is a political activist who hates corruption at all levels and wants to help purge Gotham City of its malfeasance. However, this idealist does not use the right methods and frequently resorts to wanton destruction.